Denise took to Twitter this afternoon in view of her 539,200 followers to hit out at Hancock's surprise arrival to the ITV show line-up.
The star, who is mum to The 1975 frontman Matty Healy, tweeted angrily: "I bet all those people living with the pain of not being ‘allowed’ to be with their loved ones in the last years of their lives will be so excited to see Matt fucking Hancock in the jungle!! How dare he!!!"
Many social media users rushed to the comments to share their views on the controversial news.
One who disagreed with Denise's comments was AlieCutting, who expressed: "I lost my mum during covid, in a nursing home where I want to be allowed to be with her at the end, but please don’t think you talk for us all.
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Denise has been very vocal on her opinions on the Conservative government over their decisions in the last few years.
Most notably, Denise expressed her anger at former PM Boris Johnson's decision to forgive Hancock after he broke coronavirus restriction measures.
She said: "For Boris Johnson to say Matt Hancock has apologised for breaking social distancing rules and this matter is closed, how f*****g dare you say this matter is closed.
"This man who has enforced the rules of social distance like no other, who had got it to the point where I, two weeks ago, was not allowed to travel in an ambulance with my terrified father who was being moved between hospitals at 84-years-old."
The mum-of-two continued: "When my dad first went into the hospital, 13 weeks ago, for three weeks, my sister and I were not allowed into that particular hospital where there was no Covid.
"We were happy to take a million tests before we went in!"
While in the jungle, Hancock has been suspended as a Conservative MP and will take on the challenge of representing the Tory party down under.
Andy Drummond, deputy chairman of the West Suffolk Conservative Association, has admitted he is looking forward to seeing Hancock "eating a kangaroo's penis" in the Bushtucker Trials.