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Daughters of men who became fathers after the age of 35 could be at a significantly higher risk of developing bowel cancer in adulthood, a study suggests.
Researchers found that women whose fathers were aged 35 or older when they were born had a 56 per cent higher risk of developing the disease by the time they were 40, compared with those whose fathers were aged 20 to 24 at the time of their birth.
Officially known as early-onset colorectal cancer (EOCRC), bowel cancer diagnosed before the age of 50 is becoming increasingly common in Britain - alongside a wide range of cancers among younger adults.
More than 2,400 people in the UK under the age of 50 are diagnosed with bowel cancer each year, with the number of cases among younger adults rising by 25 per cent over the past decade.
Cancer researchers have long suspected that changes to modern diets and lifestyles are helping to drive the worrying surge.
But scientists behind the new study, published in medical journal CANCER, said their findings now suggest that 'paternal age may influence risk of early onset colorectal cancer'.
The team, led by Yale University, analysed more than 1,200 cases of bowel cancer under 40 - rather than the typical 50 when looking at EOCRC - and compared them with more than 61,000 people without the disease.
While daughters were found to be at a 56 per cent higher risk, sons of fathers older than 35 were found to be at a just 7 per cent higher risk - though researchers said this was 'not statistically significant'.
Daughters of men who became fathers after the age of 35 could be at a significantly higher risk of developing bowel cancer in adulthood, a study suggests
The team believe a possible explanation for their findings is that previous studies have found older fathers have been linked to genetic mutations in their children.
They cited previous research linking greater paternal age to complications including stillbirth. They also said there have also been links to children being born with an opening in the roof of the mouth - known as a cleft palate - as well as acute lymphoblastic leukaemia, which is a fast-growing blood and bone marrow cancer, and retinoblastoma, a rare eye cancer.
Scientists believe this may help explain the higher bowel cancer risk found in the new study, though they urged caution and stressed that further research is required.
As the study was observational, it also cannot prove that becoming a father later in life causes bowel cancer - only that there is a link between the two in their research.
Beyond a father's age, the study found a wider range of factors linked to a higher risk of developing the cancer beyond a father's age, including birth weight.
Researchers uncovered that, for every 500g increase in weight at the point of birth, women were at a 10 per cent greater risk of developing bowel cancer.
The study also found that men were 34 per cent more likely than women overall to develop the disease before 40.
Meanwhile, Hispanic people were at a 43 per cent higher risk of developing the disease than non-Hispanic white people, while those with foreign-born mothers had a 15 per cent lower risk.
Sunny Siddique, the study's lead author from Yale School of Public Health, said: 'Evaluating demographic, birth, and parental characteristics is important in understanding what's causing the rising incidence of early-onset colorectal cancer.
'Our findings warrant future studies aimed to understand the mechanisms through which factors such as male sex, Hispanic ethnicity, birthweight, maternal birthplace, and paternal age may influence risk of early onset colorectal cancer.'
The findings come amid growing concerns about the rise in bowel cancer among young adults.
Dawson's Creek star James Van Der Beek tragically died after a two-year battle with the disease in February, aged just 48.
Dawson's Creek star James Van Der Beek died after a two-year battle with bowel cancer aged just 48
Analyses last year uncovered that bowel cancer cases are on the rise in under 50s across nations including Britain, Australia and Canada.
Dr Ahmedin Jemal, senior vice president of surveillance, prevention and health services research at the ACS, said previously: 'It's clear that colorectal cancer can no longer be called an old person's disease.
'We must double down on research to pinpoint what is driving this tsunami of cancer in generations born since 1950.'
Around 44,000 cases of bowel cancer are diagnosed every year in the UK, with about 130,000 in the US.
The disease kills almost 17,000 Britons each year - making it the nation's second-most common cause of cancer death behind lung cancer - with the death toll rising to about 50,000 in America.
Overall, just over half of bowel cancer patients are expected to be alive 10 years after their diagnosis.
Cancer Research UK estimates that more than half - 54 per cent - of bowel cancer cases are preventable.
Experts say incorporating a healthy diet, reducing body weight, exercising more, and cutting back on alcohol and smoking are all lifestyle choices that can reduce risk.
Symptoms of the disease can include changes in bowel habits, such as looser stools, unusual diarrhoea or constipation.
Needing to use the toilet more often, finding red or black blood in the stool, or bleeding from the back passage are also warning signs.
Other possible symptoms include stomach pain, bloating, a lump in the stomach, unexplained weight loss, fatigue, or shortness of breath - signs that may indicate anaemia caused by bowel cancer.